Evolution of the clinical scoring and classification system for acute－on－chronic liver failure / 临床肝胆病杂志

Acute－on－chronic liver failure （ACLF） has complex pathogeneses， difficulties in clinical treatment， and poor prognosis. Due to the differences in the distribution of chronic liver diseases in different countries and regions， more than ten scoring and classification systems for ACLF have been proposed in the past few decades， indicating that there are great differences in the definition， scoring， and classification of ACLF. By analyzing the characteristics of several widely used scoring and classification systems， this article discusses their evolution process and the classification criteria applicable to China， so as to provide a reference for optimizing treatment regimens.